Lysergic acid N,N-diethylamide (LSD, lysergide) is perhaps
one of the most intriguing psychoactive substances known, given
how strongly it has impacted scientific and cultural events. The psychoactive properties of LSD were discovered serendipitously by Dr
Albert Hofmann in 1943. Subsequently, numerous structural
modifications of the prototypical lysergamide scaffold have been explored, forming the basis for investigations into the nature of
the receptor binding and functional activity of LSD. In some
cases, information about the effects of several lysergamides in
humans is available.

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